Our Science
Our core tenet follows the veterinarian’s creed, which is the same as a doctor’s creed: Do no harm.
What does that mean? We carefully select functional ingredients that have multiple clinical studies that back their efficacy in our targeted function.
But what truly sets us apart? This also means we intentionally exclude ingredients that may have evidence of doing harm. You can find specific research behind our formulations for each product below.
JoyFull Prebiotic Squeeze Treats for Dogs
- Low-level fructan supplementation of dogs enhances nutrient digestion and modifies stool metabolite concentrations, but does not alter fecal microbiota populations (Hernot, et. al, 2009) – the full beneficial effects of fructans probably will not be experienced unless dietary concentrations are above 0.4% of dry food (our treat is formulated to be 1% inulin to see positive benefits)
- Effects of inulin or yeast cell-wall extract on nutrient digestibility, fecal fermentative end-product concentrations, and blood metabolite concentrations in adult dogs fed raw meat-based diets (Beloshapka, et. al, 2011) – a significant increase in fecal short-chain fatty acid concentrations was evident when dogs were fed beef-based diets with inulin and yeast.
- Responses of feeding prebiotics on nutrient digestibility, faecal microbiota composition and short-chain fatty acid concentrations in dogs: a meta-analysis (Patra, 2011) – Prebiotics at doses up to 1.4% food intake might increase the beneficial bacterial populations.
JoyFull Prebiotic Squeeze Treats for Cats
- Dietary Inulin Supplementation Modulates Fecal Microbiota and Vaccine Response in Cats – A Double-Blind Randomized Controlled Pilot Study (Jeusette, et. all, 2024) – Feeding diets containing 0.6% inulin for six weeks led to significant microbiome changes and a boost in immune response.
- Effects of inulin on fecal microbiota and specific immunity in cats – 50 mg/kg/d inulin fed significantly improved immune performance and increased beneficial intestinal bacterial flora in cats.
JoyFull Probiotic Supplement for Dogs
- Alterations in Healthy Adult Canine Faecal Microbiome and Selected Metabolites as a Result of Feeding a Commercial Complete Synbiotic Diet with Enterococcus faecium NCIMB 10415 - Soft stools were less frequent in dogs fed a diet with the probiotic Enterococcus faecium included in the diet at 10415 10^9 CFU/kg.
- Evaluation of Metronidazole With and Without Enterococcus Faecium SF68 in Shelter Dogs With Diarrhea - The supplementation of E. faecium at 5 × 10^8 CFU per day as well as an antibiotic (rather than the antibiotic alone) significantly increased the percentage of days with normal stools with successful elimination of giardia cysts.
- Effects of probiotic Lactobacillus acidophilus D2/CSL (CECT 4529) on the nutritional and health status of boxer dogs - Dogs given L. acidophilus 5.0 x 10^9 cfu/kg of food had higher body condition scores as well as higher faecal scores (with both lower faecal moisture and harder faeces).
- Effects of a probiotic Lactobacillus acidophilus strain on feed tolerance in dogs with non-specific dietary sensitivity - Feeding the probiotic L. acidophilus in a diet at 6 x 10^6 cfu/g improved faecal consistency, faecal dry matter and defecation frequency in dogs with non-specific dietary sensitivities, stabilising digestion.
- Supplementation of food with Enterococcus faecium (SF68) stimulates immune functions in young dogs - Supplementing E. faecium 5 x 10^8 cfu/d to young dogs led to significant boosts to their immune system and increased response to vaccination.
- Dietary supplementation with probiotics promotes weight loss by reshaping the gut microbiome and energy metabolism in obese dogs - E faecium stimulated dopamine synthesis in a canine model. This led to the restoration of normal eating behavior and improved glucose and insulin tolerance.
- A canine-specific probiotic product in treating acute or intermittent diarrhea in dogs: A double-blind placebo-controlled efficacy study - Administering L. acidophilus at 2×10^9cfu/ml improved wellbeing by maintaining appetite in acute diarrhea dogs.
JoyFull Probiotic Supplement for Cats
- Effect of the probiotic Enterococcus faecium SF68 on presence of diarrhea in cats and dogs housed in an animal shelter - Cats fed SF68 had fewer episodes of diarrhea of ≥2 days when compared with controls
- Effect of Enterococcus Faecium Strain SF68 on Gastrointestinal Signs and Fecal Microbiome in Cats Administered Amoxicillin-Clavulanate - The results show administering amoxicillin-clavulanate orally to cats commonly induces diarrhea and alters the gastrointestinal microbiome, and that feeding the probiotic SF68 can lessen some associated clinical abnormalities.
- Pilot study to evaluate the effects of oral supplementation of Enterococcus faecium SF68 on cats with latent feline herpesvirus 1 - While clinical results varied among individual cats, the overall findings suggest that administration of the probiotic lessened morbidity associated with chronic FHV-1 infection in some cats.